Reaktion #629104

Reaktionsgleichung

2,5-dichloro-N-methyl-N-[3-(tetrahydro-2H-pyran-2-yloxy)phenyl]pyrimidin-4-amine

2-(3-aminophenyl)ethanol

→

desired compound

Ausbeute 59.0%

3-[(5-Chloro-2-{[3-(2-hydroxyethyl)phenyl]amino}pyrimidin-4-yl)(methyl)amino]phenol

Ausbeute 59.0%

Reaktionsbedingungen

Vorschrift

The desired compound was prepared according to the procedure of Example D5, step B, using 2,5-dichloro-N-methyl-N-[3-(tetrahydro-2H-pyran-2-yloxy)phenyl]pyrimidin-4-amine and 2-(3-aminophenyl)ethanol [Bioorg. Med. Chem. 2005, 13, 6703-6712] as the starting materials in 59% yield. LCMS for C19H20ClN4O2 (M+H)+: m/z=371.1.

Quelle