Reaktion #62892

ord-a63a660d5d9b4148a844437c0c83cb1a

Reaktionsgleichung

CCOC(=O)C1C(=O)N(C)C(=O)N(C)C1=O
1,3-dimethyl-5-ethoxycarbonylbarbituric acid
COc1cc(N)ccc1O
4-hydroxy-3-methoxyaniline
CCO
ethanol
→
COc1cc(NC(=O)C2C(=O)N(C)C(=O)N(C)C2=O)ccc1O
1,3-dimethyl-5-(4-hydroxy-3-methoxyphenylcarbamoyl)barbituric acid

Edukte

CCOC(=O)C1C(=O)N(C)C(=O)N(C)C1=O
1,3-dimethyl-5-ethoxycarbonylbarbituric acid
COc1cc(N)ccc1O
4-hydroxy-3-methoxyaniline
CCO
ethanol

Reagenzien

Keine

Lösungsmittel

Cc1ccccc1
toluene

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Temperaturthe suspension is heated
  2. 2
    Sonstigeis isolated by filtration
  3. 3
    Waschenwashed with ethanol
  4. 4
    Sonstigedried

Vorschrift

6.85 g of 1,3-dimethyl-5-ethoxycarbonylbarbituric acid and 4.2 g of 4-hydroxy-3-methoxyaniline are suspended in 60 ml of toluene, and the suspension is heated under reflux for 3 hours, whereupon ethanol escapes. On cooling to room temperature a precipitate forms which is isolated by filtration, washed with ethanol and dried. Yield: 8.3 g (86% of theory). Melting point: 252°-253° C.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04762830uspto-grants-1988_08