Reaktion #62859

ord-25edcd85ecdb428288232c70d29b3d78

Reaktionsgleichung

Cc1cc(Cl)c(C(=O)O)cc1C
2-chloro-4,5-dimethylbenzoic acid
O=S(=O)(O)O
H2SO4
O=[N+]([O-])[O-].[K+]
KNO3
→
Cc1cc(C(=O)O)c(Cl)c([N+](=O)[O-])c1C
2-chloro-4,5-dimethyl-3-nitro-benzoic acid

Edukte

Cc1cc(Cl)c(C(=O)O)cc1C
2-chloro-4,5-dimethylbenzoic acid
O=S(=O)(O)O
H2SO4
O=[N+]([O-])[O-].[K+]
KNO3

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Temperaturwhile cooling with ice
  2. 2
    TemperaturThe mixture is subsequently warmed to 50° for a further 2 hours
  3. 3
    workup.ADDITIONpoured onto ice
  4. 4
    SonstigeThe product is isolated
  5. 5
    Sonstigerecrystallized from toluene

Vorschrift

31.6 g of 2-chloro-4,5-dimethylbenzoic acid are initially introduced into 94 ml of H2SO4. 19 g of KNO3 are added in portions, while cooling with ice. The mixture is subsequently warmed to 50° for a further 2 hours and then poured onto ice. The product is isolated and recrystallized from toluene. Yield: 25.3 g, melting point: 160°-63°.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04762844uspto-grants-1988_08