Reaktion #62803

ord-96343b46141444b4b664ef971c0ef02e

Reaktionsgleichung

CCOC(=O)CC(=O)c1cc(F)c(Cl)c([N+](=O)[O-])c1Cl
ethyl(2,4-dichloro-5-fluoro-3-nitrobenzoyl)acetate
CCOC(OCC)OCC
triethyl orthoformate
CC(=O)OC(C)=O
acetic anhydride
→
CCOC=C(C(=O)OCC)C(=O)c1cc(F)c(Cl)c([N+](=O)[O-])c1Cl
Ethyl 2-(2,4-dichloro-5-fluoro-3-nitrobenzoyl)-3-ethoxyacrylate

Edukte

CCOC(=O)CC(=O)c1cc(F)c(Cl)c([N+](=O)[O-])c1Cl
ethyl(2,4-dichloro-5-fluoro-3-nitrobenzoyl)acetate
CCOC(OCC)OCC
triethyl orthoformate
CC(=O)OC(C)=O
acetic anhydride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    EinengenThe mixture is then concentrated in vacuo, and 270 g of ethyl benzoylethoxyacrylate
  2. 2
    Sonstigeare obtained as an oily residue

Vorschrift

244.8 g of ethyl(2,4-dichloro-5-fluoro-3-nitrobenzoyl)acetate are heated with 166 g of triethyl orthoformate and 185 g of acetic anhydride at 150°-160° C. for 3 hours. The mixture is then concentrated in vacuo, and 270 g of ethyl benzoylethoxyacrylate are obtained as an oily residue.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04762831uspto-grants-1988_08