Reaktion #627481

Reaktionsgleichung

2,4-dichloro-6-methylquinazoline

3-(aminomethyl)-N,N-dibenzyloxetan-3-amine

triethylamine

→

product

2-Chloro-N-{[3-(dibenzylamino)oxetan-3-yl]methyl}-6-ethylquinazolin-4-amine

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenthe mixture was concentrated in vacuo
2. 2
   SonstigeThe residue was purified by flash column chromatography (eluting with 20% ethyl acetate in petroleum ether)

Vorschrift

A solution of 2,4-dichloro-6-methylquinazoline (1.0 g, 4.69 mmol) in methanol (10 mL) was added 3-(aminomethyl)-N,N-dibenzyloxetan-3-amine (1.4 g, 5.16 mmol, 60% purity) and triethylamine (0.1 g, 1 mmol). After being stirred at room temperature overnight, the mixture was concentrated in vacuo. The residue was purified by flash column chromatography (eluting with 20% ethyl acetate in petroleum ether) to afford 1.6 g of the product as a white solid (yield was 76%).

Quelle