Reaktion #627436

Reaktionsgleichung

2,4-dichloro-6-methylquinazoline

tert-butyl N-(2-aminoethyl)carbamate

→

product

Ausbeute 91.0%

tert-Butyl {2-[(2-chloro-6-methylquinazolin-4-yl)amino]ethyl}carbamate

Ausbeute 91.0%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe resulting mixture was concentrated in vacuo
2. 2
   Sonstigethe residue was purified by flash column chromatography

Vorschrift

A mixture of 2,4-dichloro-6-methylquinazoline (700 mg, 3.29 mmol), tert-butyl N-(2-aminoethyl)carbamate (2.6 g, 16.4 mmol) and methanol (35 mL) was stirred at room temperature for 1 hour. The resulting mixture was concentrated in vacuo and the residue was purified by flash column chromatography to afford 1.0 g of the product as a white solid (yield was 91%).

Quelle