Reaktion #627434

Reaktionsgleichung

2,4-dichloro-6-methylquinazoline

triethylamine

2,2-dimethyl-1,3-dioxolane-4-methanamine

→

crude product

Ausbeute 100.0%

2-Chloro-N-[(2,2-dimethyl-1,3-dioxolan-4-yl)methyl]-6-methylquinazolin-4-amine

Ausbeute 100.0%

Lösungsmittel

methanol

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwashed with brine (50 mL×2)
2. 2
   Trocknendried over anhydrous sodium sulfate
3. 3
   Einengenconcentrated in vacuo

Vorschrift

A solution of 2,4-dichloro-6-methylquinazoline (300.0 mg, 1.4 mmol), triethylamine (0.5 mL) and 2,2-dimethyl-1,3-dioxolane-4-methanamine (0.2 mL, 1.5 mmol) in methanol (2.0 mL) was stirred at room temperature for 16 hours. The reaction mixture was diluted with ethyl acetate (100 mL), washed with brine (50 mL×2), dried over anhydrous sodium sulfate and then concentrated in vacuo to afford 431 mg of the crude product as a white solid. MS obsd. (ESI+) [(M+H)+] 308.

Quelle