Reaktion #627399

Reaktionsgleichung

acetic acid

2,4-dichloro-6-methylquinazoline

sodium hydroxide

→

desired product

Ausbeute 87.6%

2-Chloro-6-methylquinazolin-4(3H)-one

Ausbeute 87.6%

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe reaction mixture was chilled
2. 2
   FiltrationThe formed solid was collected by filtration
3. 3
   Waschenwashed with water
4. 4
   Sonstigedried in vacuo

Vorschrift

To a solution of 2,4-dichloro-6-methylquinazoline (2.13 g, 10 mmol) in tetrahydrofuran (20 mL) was added sodium hydroxide (2 N, 20 mL). After being stirred at room temperature for 4 hours, the reaction mixture was chilled and acidified to pH 5 with acetic acid. The formed solid was collected by filtration, washed with water, and dried in vacuo to afford 1.7 g of the desired product as a white solid (yield was 87.6%).

Quelle