Reaktion #627394

Reaktionsgleichung

2,4-dichloro-6-methylquinazoline

2-methylpropane-1,2-diamine

→

desired product

Ausbeute 80.6%

N˜1˜-(2-Chloro-6-methylquinazolin-4-yl)-2-methylpropane-1,2-diamine

Ausbeute 80.6%

Lösungsmittel

ethyl acetate

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe formed solid was collected by filtration
2. 2
   Sonstigedried in vacuo

Vorschrift

A solution of 2,4-dichloro-6-methylquinazoline (500 mg, 2.35 mmol) and 2-methylpropane-1,2-diamine (365 μL, 3.52 mmol) in methanol (10 mL) was stirred at room temperature for 1 hour. The reaction mixture was diluted with ethyl acetate (30 mL) and stirred for 30 minutes. The formed solid was collected by filtration and dried in vacuo to afford 500 mg of the desired product as a white solid (yield was 80.6%).

Quelle