Reaktion #627391

Reaktionsgleichung

2,4-dichloro-6-methylquinazoline

ammonia

→

crude product

2-Chloro-6-methylquinazolin-4-amine

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe resulting mixture was concentrated in vauco

Vorschrift

A mixture of 2,4-dichloro-6-methylquinazoline (500 mg, 2.348 mmol) and a solution of ammonia in tetrahydrofuran (20 mL, 3.0 M) was stirred in an ice-bath for 2 hours. The resulting mixture was concentrated in vauco to afford 454 mg of the crude product as a white solid.

Quelle