Reaktion #627373

Reaktionsgleichung

2,4-dichloro-6-methylquinazoline

3-(aminomethyl)oxetan-3-amine

→

desired product

N-(3-Aminooxetan-3-ylmethyl)-2-chloro-6-methylquinazolin-4-amine

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenAfter the resulting mixture was concentrated in vacuo
2. 2
   Sonstigethe residue was purified by column chromatography (eluting with 10% methanol in dichloromethane)

Vorschrift

A solution of 2,4-dichloro-6-methylquinazoline (645 mg, 3 mmol) and 3-(aminomethyl)oxetan-3-amine (340 mg, 3.3 mmol) in methanol (15 mL) was stirred at room temperature overnight. After the resulting mixture was concentrated in vacuo, the residue was purified by column chromatography (eluting with 10% methanol in dichloromethane) to afford the desired product.

Quelle