Reaktion #62720

Reaktionsgleichung

maleic anhydride

2,4-diamino-5-(7,8-dimethoxy-2H-1-benzopyran-5-ylmethyl)pyrimidine

maleic acid

→

title compound

Ausbeute 94.9%

2,4-Diamino-5-(7,8-dimethoxy-2H-1-benzopyran-5-ylmethyl)pyrimidine Maleate

Ausbeute 94.9%

Lösungsmittel

water

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationthe crystalline salt was filtered
2. 2
   Waschenwashed with cold water
3. 3
   Sonstigedried at 72° C.

Vorschrift

To 2,4-diamino-5-(7,8-dimethoxy-2H-1-benzopyran-5-ylmethyl)pyrimidine (3.90 g, 12.4 mmol) in 200 mL of boiling water was added a solution of maleic acid, prepared by dissolution of maleic anhydride (1.25 g, 12.7 mmol) in 50 mL of hot water. After cooling to 0° C., the crystalline salt was filtered, washed with cold water, and dried at 72° C. to give 5.07 g (94.9%) of the title compound. Anal. Calcd for C20H22N4O7 : C, 55.81; H, 5.15; N, 13.02. Found: C, 55.78; H, 5.18; N, 12.98.

Quelle