Reaktion #62705

Reaktionsgleichung

1-ethoxyiminobutyl-3-hydroxy-5-(tetrahydrothiopyran-3-yl)cyclohex-2-en-1-one

triethylamine

thionyl chloride

→

3-Chloro-2-(1-ethoxyiminobutyl)-5-(tetrahydrothiopyran-3-yl)cyclohex-2-en-1-one

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationAfter 3 hours the resulting precipitate was filtered off with suction
2. 2
   Waschenwashed with tetrahydrofuran
3. 3
   Einengenthe product-containing filtrate was concentrated

Vorschrift

10.0 g (31 mmol) of 2-(1-ethoxyiminobutyl-3-hydroxy-5-(tetrahydrothiopyran-3-yl)cyclohex-2-en-1-one were dissolved in 50 ml of tetrahydrofuran, and 4.7 ml of triethylamine were added, followed by 2.3 ml of thionyl chloride. After 3 hours the resulting precipitate was filtered off with suction, and washed with tetrahydrofuran, and the product-containing filtrate was concentrated. 3-Chloro-2-(1-ethoxyiminobutyl)-5-(tetrahydrothiopyran-3-yl)cyclohex-2-en-1-one was obtained as an oil (compound no. 90).

Quelle