Reaktion #6270

Reaktionsgleichung

2,4-thiazolidinedione

3,5-di-tert-butyl-4-hydroxybenzaldehyde

piperidine

→

desired compound

5-(3,5-di-tert-butyl-4-hydroxyphenyl)-methylene-2,4-thiazolidinedione

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe mixture was heated
2. 2
   Temperaturunder reflux for 5 hours
3. 3
   TemperaturAfter cooling
4. 4
   Filtrationthe precipitated crystals were filtered
5. 5
   Waschenwashed with cooled ethanol

Vorschrift

To a solution of 12.5 g (107 mmol) of 2,4-thiazolidinedione and 25.0 g (107 mmol) of 3,5-di-tert-butyl-4-hydroxybenzaldehyde in 300 ml of ethanol, 1.05 ml (10.7 mmol) of piperidine was added, and the mixture was heated under reflux for 5 hours. After cooling, the precipitated crystals were filtered and washed with cooled ethanol to give 15.23 g of the desired compound (42.8% yield, pale yellow crystals).

Quelle