Reaktion #626945

Reaktionsgleichung

6-chloro-3-methyl-2-phenylimidazo[1,2-b]pyridazine

1-(4-fluorobenzyl)piperazine

triethylamine

→

title product

Ausbeute 81.0%

6-(4-(4-fluorobenzyl)piperazin-1-yl)-3-methyl-2-phenylimidazo[1,2-b]pyridazine

Ausbeute 81.0%

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe reaction mixture is concentrated to dryness
2. 2
   Sonstigepurified via chromatography (hexanes to EtOAc)

Vorschrift

A solution of 6-chloro-3-methyl-2-phenylimidazo[1,2-b]pyridazine (1.00 g, 4.35 mmol) and 1-(4-fluorobenzyl)piperazine (Sigma-Aldrich, 1.54 g, 4.35 mmol) in acetonitrile (50 mL) containing triethylamine (13.0 mmol) is heated at 180° C. in the microwave for 5 hours. The reaction mixture is concentrated to dryness and then purified via chromatography (hexanes to EtOAc) to afford the title product (0.82 g, 81%) as an off-white solid: Rf 0.30 (EtOAc); LCMS (m/z)=402.4 [M+H]+, tR=1.74 min. (compound same as Example 134)

Quelle