Reaktion #626944

Reaktionsgleichung

6-chloropyridazin-3-amine

2-bromo-1-phenylpropan-1-one

→

title compound

Ausbeute 81.0%

6-chloro-3-methyl-2-phenylimidazo[1,2-b]pyridazine

Ausbeute 81.0%

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe mixture is concentrated to dryness
2. 2
   Sonstigepurified via chromatography (hexanes to EtOAc)

Vorschrift

A stirred solution of 6-chloropyridazin-3-amine (1.00 g, 7.71 mmol) and 2-bromo-1-phenylpropan-1-one (Sigma-Aldrich, 1.54 g, 7.71 mmol) in acetonitrile (50 mL) is heated at 80° C. for 16 hours. The mixture is concentrated to dryness and purified via chromatography (hexanes to EtOAc) to afford the title compound (1.52 g, 81%) as a tan solid: Rf 0.52 (1:1 EtOAc:hexanes); LCMS (m/z)=244.2, 246.3 [M+H]+, tR=2.61 min.

Quelle