Reaktion #6264

Reaktionsgleichung

2,4-thiazolidinedione

benzaldehyde

piperidine

→

desired compound

Ausbeute 90.4%

5-benzylidene-2,4-thiazolidinedione

Ausbeute 90.4%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe mixture was heated
2. 2
   Temperaturunder reflux for 5 hours
3. 3
   TemperaturAfter cooling
4. 4
   Filtrationthe precipitated crystals were filtered
5. 5
   Waschenwashed with cooled ethanol

Vorschrift

To a solution of 20 g (171 mmol) of 2,4-thiazolidinedione and 17.4 ml (171 mmol) of benzaldehyde in 350 ml of ethanol, 1.68 ml (17.1 mmol) of piperidine was added, and the mixture was heated under reflux for 5 hours. After cooling, the precipitated crystals were filtered and washed with cooled ethanol to give 31.67 g of the desired compound (90.4% yield, pale yellow crystals).

Quelle