Reaktion #62630

ord-ddb6f947abfe4960a293ee423c4a3354

Reaktionsgleichung

CSc1ccc(N2CCc3ccccc32)c(NC(=O)N2CCN(C)CC2)c1
N-[5-methylthio-2-(2,3-dihydro-1H-indol-1-yl)phenyl]-4-methyl-1-piperazinecarboxamide
C1=Cc2ccccc2NN=C1
benzodiazepine
→
CSc1ccc2c(c1)N=C(N1CCN(C)CC1)c1cccc3c1N2CC3
9-Methylthio-6-(4-methyl-1-piperazinyl)-1,2-dihydrobenzo[b]pyrrolo[3,2,1-jk][1,4]benzodiazepine

Edukte

CSc1ccc(N2CCc3ccccc32)c(NC(=O)N2CCN(C)CC2)c1
N-[5-methylthio-2-(2,3-dihydro-1H-indol-1-yl)phenyl]-4-methyl-1-piperazinecarboxamide
C1=Cc2ccccc2NN=C1
benzodiazepine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigewill be obtained

Vorschrift

It is predicted that if the N-[5-methylthio-2-(2,3-dihydro-1H-indol-1-yl)phenyl]-4-methyl-1-piperazinecarboxamide of Example 10c is treated in the manner of Example 4c that 9-methylthio-6-(4-methyl-1-piperazinyl)-1,2-dihydrobenzo[b]pyrrolo[3,2,1-jk]-1,4]benzodiazepine will be obtained.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04761412uspto-grants-1988_08