Reaktion #625862

Reaktionsgleichung

benzyl bromide

piperidine-2-ethanol

K2CO3

→

compound 49

2-(1-Benzylpiperidin-2-yl)ethanol

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationfiltered through a sintered funnel
2. 2
   Einengenconcentrated
3. 3
   workup.DISSOLUTIONThe crude material was dissolved in ethyl acetate
4. 4
   Waschenthe organic layer was washed with water and brine
5. 5
   Trocknendried over anhydrous Na2SO4
6. 6
   Filtrationfiltered
7. 7
   Einengenconcentrated

Vorschrift

To a stirred solution of piperidine-2-ethanol (20 g, 155 mmol) in ethanol (240 mL) was added K2CO3 (106 g, 775.1 mmol) followed by addition of benzyl bromide (18.4 mL, 155.04 mmol) at 0° C. The reaction mixture was stirred at rt overnight, filtered through a sintered funnel and concentrated. The crude material was dissolved in ethyl acetate, the organic layer was washed with water and brine, dried over anhydrous Na2SO4, filtered and concentrated to get liquid compound 49.

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