Reaktion #62548

Reaktionsgleichung

Methyl chloroacetate

N-methylpiperazine

→

2-(4-methyl-1-piperazinyl)acetic acid, methyl ester

Ausbeute 95.0%

Lösungsmittel

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe reaction mixture was filtered
2. 2
   Sonstigethe solvent was removed under vacuum
3. 3
   workup.DISSOLUTIONThe resulting oil was dissolved in methylene chloride-methanol (9:1)
4. 4
   Sonstigepurified by flash chromatography (silica)

Vorschrift

Methyl chloroacetate (8.8 ml., 0.10 mole) was added to a solution of N-methylpiperazine (24.4. ml., 0.22 mole) in ethyl acetate (140 ml.) and the mixture was stirred for 17 hours. The reaction mixture was filtered and the solvent was removed under vacuum. The resulting oil was dissolved in methylene chloride-methanol (9:1) and purified by flash chromatography (silica) to give 2-(4-methyl-1-piperazinyl)acetic acid, methyl ester as an oil (16.3 g, 95%).

Quelle