Reaktion #625241

Reaktionsgleichung

(trans-4-aminomethyl-cyclohexyl)-(4-cyclopropanecarbonyl-piperazin-1-yl)-methanone

DMF

4-chloro-2-fluoronitrobenzene

→

titled compound

Ausbeute 83.6%

{trans-4-[(5-Chloro-2-nitro-phenylamino)-methyl]-cyclohexyl}-(4-cyclopropanecarbonyl-piperazin-1-yl)-methanone

Ausbeute 83.6%

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThen the solvent was removed under reduced pressure
2. 2
   Waschenthe residue was washed with 7 mL of H2O
3. 3
   Filtrationthe precipitate was filtered

Vorschrift

To a solution of (trans-4-aminomethyl-cyclohexyl)-(4-cyclopropanecarbonyl-piperazin-1-yl)-methanone (600 mg, 2.1 mmol) in DMF (5 mL) K2CO3 (565 mg, 4.1 mmol) and 4-chloro-2-fluoronitrobenzene (360 mg, 2.1 mmol) were added and the mixture was heated at 90° C. for 4 hours. Then the solvent was removed under reduced pressure and the residue was washed with 7 mL of H2O and the precipitate was filtered affording 788 mg of the titled compound (78% yield).

Quelle