Reaktion #62477
ord-e29450108c6a45b3829785274f94d6f4
Reaktionsgleichung
6-chloro-4-[1-(5-chloro-1H-benzimidazol-2-yl)-ethylamino]-7-hydroxycarbonyl-quinazoline
pentafluorophenyl-tetramethyluronium hexafluorophosphate
diisopropylethylamine
3-dimethylamino-pyrrolidine
→
6-chloro-4-[(1R/S)-1-(5-chloro-1H-benzimidazol-2-yl)-ethylamino]-7-[(3R/S)-3-dimethylamino-pyrrolidin-1-yl-carbonyl]-quinazoline
Edukte
Reagenzien
Keine
Lösungsmittel
Reaktionsbedingungen
Detaillierte Bedingungen
See reaction.notes.procedure_details.
Vorschrift
Prepared analogously to Example 37a from 6-chloro-4-[1-(5-chloro-1H-benzimidazol-2-yl)-ethylamino]-7-hydroxycarbonyl-quinazoline, pentafluorophenyl-tetramethyluronium-hexafluorophosphate (PFTU), diisopropylethylamine and 3-dimethylamino-pyrrolidine in DMSO at ambient temperature.