Reaktion #62386

Reaktionsgleichung

ethanol

3-iodo-1-trityl-1H-pyrazolo[3,4-c]pyridine-5-carbonitrile

lithium hydroxide

hydrochloric acid

→

title compound

3-Iodo-1-trityl-1H-pyrazolo[3,4-c]pyridine-5-carboxylic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturheated
2. 2
   Temperaturat reflux for a day
3. 3
   Filtrationthe precipitated crystals were collected by filtration
4. 4
   WaschenThe crystals were washed successively with water and diethyl ether

Vorschrift

To a suspension of 3.0 g of 3-iodo-1-trityl-1H-pyrazolo[3,4-c]pyridine-5-carbonitrile obtained by Production example 431 in 20 mL of ethanol was added 20 mL of 4N lithium hydroxide aqueous solution at room temperature, and heated at reflux for a day. After cooling to room temperature, the solution was neutralized with 5N hydrochloric acid aqueous solution, and the precipitated crystals were collected by filtration. The crystals were washed successively with water and diethyl ether, to afford 3.0 g of the title compound as colorless crystals.

Quelle