Reaktion #623650

Reaktionsgleichung

solution

6-fluoro-2H-chromene-3-carbonitrile

→

title compound

(6-fluorochroman-3-yl)methanamine

Lösungsmittel

NH3

MeOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.WAITAfter 3 hours
2. 2
   Filtrationthe solution was filtered
3. 3
   Einengenconcentrated
4. 4
   SonstigeThe resulting residue was purified by silica gel chromatography (gradient elution: 1-15% MeOH/CH2Cl2 with 1% NH4OH)

Vorschrift

To a solution of Example 28A (780 mg, 4.45 mmol) in 7M NH3 in MeOH (5.00 mL) was added to Ra—Ni 2800 water slurry (1.56 g, 26.6 mmol) in a 50 mL pressure bottle. The reaction mixture was and stirred for 10 hours at 30 psi at ambient temperature. After 3 hours, the solution was filtered and concentrated. The resulting residue was purified by silica gel chromatography (gradient elution: 1-15% MeOH/CH2Cl2 with 1% NH4OH) to provide the title compound. MS (DCI+) m/z 182 (M+H)+.

Quelle