Reaktion #62343

Reaktionsgleichung

2-amino-4-methyl-5-nitropyridine

isopentyl sulfite

diiodomethane

→

title compound

2-Iodo-4-methyl-5-nitropyridine

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGthe solution was stirred for 2 hours
2. 2
   SonstigeThe diiodomethane was evaporated
3. 3
   Sonstigethe crude product was purified
4. 4
   Sonstigeseparated by silica gel column chromatography (ethyl acetate:n-hexane=1:20)

Vorschrift

To a solution of 1.0 g of 2-amino-4-methyl-5-nitropyridine in 10 mL of diiodomethane was added 1.8 mL of isopentyl sulfite at room temperature, stirred at this temperature for 30 minutes, and after raising the temperature to 80° C., the solution was stirred for 2 hours. The diiodomethane was evaporated, and the crude product was purified and separated by silica gel column chromatography (ethyl acetate:n-hexane=1:20), to afford 897 mg of the title compound as colorless crystals.

Quelle