Reaktion #623015

Reaktionsgleichung

1-methyl-4-nitro-2-trifluormethylbenzene

NBS

AIBN

→

1-(Bromomethyl)-2-(trifluoromethyl)-4-nitrobenzene

Lösungsmittel

carbon tetrachloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction was refluxed overnight
2. 2
   Sonstigepartitioned with water
3. 3
   SonstigeThe organic layer was separated
4. 4
   Extraktionthe aqueous layer was extracted with CH2Cl2
5. 5
   WaschenThe combined organic extracts were washed with water
6. 6
   Trocknendried over Na2SO4
7. 7
   Filtrationfiltered
8. 8
   Einengenconcentrated
9. 9
   Sonstigeto afford the material that
10. 10
    Sonstigewas not purified

Vorschrift

Into a solution of 1-methyl-4-nitro-2-trifluormethylbenzene (4.1 g, 20 mmol) in carbon tetrachloride (30 mL) were added NBS (5.4 g, 30 mmol) and AIBN (493 mg, 3 mmol). The reaction was refluxed overnight and then partitioned with water. The organic layer was separated and the aqueous layer was extracted with CH2Cl2. The combined organic extracts were washed with water, dried over Na2SO4, filtered and concentrated to afford the material that was not purified but used directly in the next step.

Quelle