Reaktion #62288

Reaktionsgleichung

(2-chlorothiophen-3-yl)-(naphthalen-2-yl)-methanol

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title compound

Ausbeute 52.1%

(2-Chlorothiophen-3-yl)-(naphthalen-2-yl)-methanone

Ausbeute 52.1%

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationmanganese dioxide was filtered off through Celite
2. 2
   workup.DISTILLATIONThe solvent was distilled off
3. 3
   Sonstigethe resultant crude product was purified
4. 4
   Sonstigeseparated by silica gel column chromatography (ethyl acetate:n-hexane=1:50)

Vorschrift

To a solution of 1.18 g of (2-chlorothiophen-3-yl)-(naphthalen-2-yl)-methanol in 12 mL of toluene was added 1.12 g of activated manganese dioxide at room temperature, and after stirring at 50° C. for a day, manganese dioxide was filtered off through Celite. The solvent was distilled off, and the resultant crude product was purified and separated by silica gel column chromatography (ethyl acetate:n-hexane=1:50), to afford 0.61 g of the title compound as a colorless oil.

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