Reaktion #622855

Reaktionsgleichung

5-fluoro-N,N-dimethyl-7-(piperazin-1-yl)benzofuran-2-carboxamide

2-(2-bromoethyl)pyridine

HBr

triethylamine

→

title compound

5-Fluoro-N,N-dimethyl-7-(4-(2-(pyridin-2-yl)ethyl)piperazin-1-yl)benzofuran-2-carboxamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe product was purified by preparative HPLC

Vorschrift

A reaction mixture of 5-fluoro-N,N-dimethyl-7-(piperazin-1-yl)benzofuran-2-carboxamide (0.10 g, 0.35 mmol), 2-(2-bromoethyl)pyridine:HBr (0.132 g, 0.49 mmol) and triethylamine (0.12 mL, 0.88 mmol) was heated at 80° C. over night. The product was purified by preparative HPLC to give the title compound. Yield: 0.091 g (65%).

Quelle