Reaktion #621846

Reaktionsgleichung

Cesium fluoride

Methyl 2-chloro-3-nitrobenzoate

→

indicated compound

Ausbeute 76.0%

methyl 2-fluoro-3-nitrobenzoate

Ausbeute 76.0%

Lösungsmittel

N,N-dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeequipped with a stirrer under a nitrogen gas stream
2. 2
   workup.STIRRINGthe reaction mixture was agitated for one hour at 140° C
3. 3
   TemperaturThe reaction mixture was naturally cooled to room temperature
4. 4
   Filtrationwas filtered
5. 5
   Einengenthe filtrate was concentrated under reduced pressure
6. 6
   workup.ADDITIONThe concentration residue was poured into water
7. 7
   workup.STIRRINGagitated for a while
8. 8
   Sonstigea solid that precipitated
9. 9
   Filtrationwas collected by filtration
10. 10
    Sonstigedried under reduced pressure

Vorschrift

Cesium fluoride (499.02 g, 3.19 mol) was added into a flask equipped with a stirrer under a nitrogen gas stream, and was agitated for one hour at 110° C. Methyl 2-chloro-3-nitrobenzoate (229.00 g, 1.06 mol) and N,N-dimethylformamide (2000 ml) were added thereto, and the reaction mixture was agitated for one hour at 140° C. The reaction mixture was naturally cooled to room temperature, and then was filtered, and the filtrate was concentrated under reduced pressure. The concentration residue was poured into water and agitated for a while, and then a solid that precipitated was collected by filtration and dried under reduced pressure. As a result, 160.03 g (yield: 76%) of the indicated compound was obtained.

Quelle