Reaktion #62169

Reaktionsgleichung

water

4-[3-(4-Benzyloxy-phenyl)-1H-pyrazol-4-yl]-pyridine

cesium carbonate

1,1,1-Trifluoro-2-iodo-ethane

→

title compound

4-[3-(4-Benzyloxy-phenyl)-1-(2,2,2-trifluoro-ethyl)-1H-pyrazol4-yl]-pyridine

Lösungsmittel

dimethyl formamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted 3× with dichloromethane
2. 2
   SonstigePurification via biotage MPLC chromatography
3. 3
   Wascheneluting with 5% methanol/0.5% ammonium hydroxide/70% ethyl acetate/hexane

Vorschrift

To a solution of 4-[3-(4-Benzyloxy-phenyl)-1H-pyrazol-4-yl]-pyridine (0.42 g) in dimethyl formamide (7 ml) was added cesium carbonate (0.65 g) and 1,1,1-Trifluoro-2-iodo-ethane (0.29 ml). The reaction mixture was heated at 60° C. for 24 h, poured into water and extracted 3× with dichloromethane. Purification via biotage MPLC chromatography, eluting with 5% methanol/0.5% ammonium hydroxide/70% ethyl acetate/hexane provided the title compound. MS: (M+H m/z=410.0).

Quelle