Reaktion #62163

Reaktionsgleichung

4-(Quinolin-2-ylmethoxy)-phenylamine

tin

sodium nitrite

→

title compound

[4-(Quinolin-2-ylmethoxy)-phenyl]-hydrazine

Lösungsmittel

HCl

HCl

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONadded slowly dropwise
2. 2
   FiltrationThe reaction mixture was filtered
3. 3
   Sonstigethe solid dried

Vorschrift

To a suspension of 4-(Quinolin-2-ylmethoxy)-phenylamine (1.73 g) in 30 mL of concentrated HCl at 0° C. was added sodium nitrite (531 mg). After 3 h, tin chlrodie (3.95 g) was dissolved in 20 mL of concentrated HCl and added slowly dropwise and the reaction mixture stirred at ambient temperature for 18 h. The reaction mixture was filtered and the solid dried to provide the title compound as the HCL salt (3.94 g). MS: (M+H m/z=266.3).

Quelle