Reaktion #62143

Reaktionsgleichung

4-(2-Quinolin-2-yl-ethyl)-benzoic acid methyl ester

methanol

sodium hydroxide

→

title compound

Ausbeute 86.0%

4-(2-Quinolin-2-yl-ethyl)-benzoic acid

Ausbeute 86.0%

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe white solid was filtered

Vorschrift

To a solution of 4-(2-Quinolin-2-yl-ethyl)-benzoic acid methyl ester (680 mg) in THF (11 ml)/methanol (3 ml) was added 1N sodium hydroxide solution (4.67 ml). The reaction mixture stirred for 4 h. and the pH adjusted to 3. The white solid was filtered to provide the title compound (550 mg, 86%). MS: (M+H m/z=278.1).

Quelle