Reaktion #621031

Reaktionsgleichung

Cs2CO3

3-biphenylol

1,3-dibromopropane

→

title compound

Ausbeute 57.9%

3-biphenylyl 3-bromopropyl ether

Ausbeute 57.9%

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenconcentrated under vacuum
2. 2
   workup.ADDITIONThe resulting residue was treated with H2O (4 mL)
3. 3
   Extraktionextracted with DCM (8 mL)
4. 4
   SonstigeThe organic layer was dried through a phase separator
5. 5
   Einengenconcentrated under vacuum
6. 6
   Sonstigepurified by preparatory HPLC (without TFA)

Vorschrift

To a solution of 3-biphenylol (0.0574 g, 0.337 mmol) in acetonitrile (4 mL) was added 1,3-dibromopropane (0.340 mL, 3.35 mmol) followed by Cs2CO3 (0.172 g, 0.529 mmol). The reaction mixture was stirred for 24 h and then concentrated under vacuum. The resulting residue was treated with H2O (4 mL) and extracted with DCM (8 mL). The organic layer was dried through a phase separator and concentrated under vacuum. The residue was taken up in DMSO and purified by preparatory HPLC (without TFA) to give the title compound (0.0568 g, 57.8%). EI-MS Rt (2.59 min).

Quelle