Reaktion #62044

Reaktionsgleichung

HCl

4-Isothiocyanato-benzoic acid t-butyl ester

4-isothiocyanato-benzoic acid t-butyl ester

KOH

cyanoacetamide

→

4-(2-Carbamoyl-2-cyano-thioacetylamino)-benzoic acid t-butyl ester

Ausbeute 83.5%

4-(2-carbamoyl-2-cyano-thioacetylamino)-benzoic acid t-butyl ester

Ausbeute 83.5%

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe precipitate obtained
2. 2
   Filtrationwas filtered
3. 3
   Waschenwashed with water
4. 4
   Sonstigedried under vacuum

Vorschrift

4-Isothiocyanato-benzoic acid t-butyl ester 2 (28.3 gm, 120.4 mmol) was taken into DMF (200 ml). To this KOH (6.74 gm, 120.4 mmol) and cyanoacetamide (10.21 gm, 120.4 mmol) were added. The reaction mixture was stirred at room temperature for 16 h. The reaction mixture was acidified with 1N HCl, the precipitate obtained was filtered, washed with water, and dried under vacuum, to provide 32.10 gm of 4-(2-Carbamoyl-2-cyano-thioacetylamino)-benzoic acid t-butyl ester 3.

Quelle