Reaktion #62036

Reaktionsgleichung

3,4-difluoronitrobenzene

2,5-dichlorophenol

potassium carbonate

→

crude product

Ausbeute 94.7%

1-(2,5-Dichloro-phenoxy)-2-fluoro-4-nitro-benzene

Ausbeute 94.7%

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter cooling to room temperature
2. 2
   workup.STIRRINGstirred for 30 min
3. 3
   FiltrationThe precipitates were collected by filtration
4. 4
   Waschenwashed with water
5. 5
   Sonstigedried in vacuo

Vorschrift

A mixture of 3,4-difluoronitrobenzene (3.2 g, 0.02 mol), 2,5-dichlorophenol (3.59 g, 0.022 mol), and potassium carbonate (3.0 g, 0.022 mol) in 25 ml of anhydrous DMF was heated to 150° C. with stirring overnight. After cooling to room temperature, the reaction mixture was poured into 500 ml of ice water and stirred for 30 min. The precipitates were collected by filtration, washed with water, and dried in vacuo to give 5.72 g (94.7%) of crude product.

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