Reaktion #61975

Reaktionsgleichung

sodium bicarbonate

4-hydroxybenzaldehyde

piperidine

sodium triacetoxyborohydride

→

title compound

4-Piperidin-1-ylmethyl-phenol

Lösungsmittel

DCE

acetic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with DCM (5×100 mL)
2. 2
   TrocknenThe combined organic phases were dried (magnesium sulfate)
3. 3
   Sonstigeevaporated

Vorschrift

A solution of 4-hydroxybenzaldehyde (10 g), piperidine (8.9 mL), and acetic acid (4.7 mL) in DCE (200 mL) was treated with sodium triacetoxyborohydride (24 g). After 16 h, the resulting mixture was treated with saturated aqueous sodium bicarbonate (100 mL) and extracted with DCM (5×100 mL). The combined organic phases were dried (magnesium sulfate) and evaporated. Trituration of the residue with ethyl acetate gave the title compound as a white crystalline solid (5.5 g).

Quelle