Reaktion #61973

Reaktionsgleichung

product

4-(3-Chloro-propoxy)-benzaldehyde

piperidine

acetic acid

sodium triacetoxyborohydride

→

title compound

1-[4-(3-Chloro-propoxy)-benzyl]-piperidine

Lösungsmittel

water

DCE

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with DCM (3×50 mL)
2. 2
   TrocknenThe combined organic phases were dried (magnesium sulfate)
3. 3
   Sonstigeevaporated

Vorschrift

A solution of the product of Example 11 (5.0 g), piperidine (3.1 mL), and acetic acid (2.0 mL) in DCE (100 mL) was treated with sodium triacetoxyborohydride (9.3 g). After 16 h, the resulting mixture was diluted with water (100 mL) and extracted with DCM (3×50 mL). The combined organic phases were dried (magnesium sulfate) and evaporated, giving the title compound as an amber oil (5.3 g).

Quelle