Reaktion #619117

Reaktionsgleichung

3-[2-(3,3-dicyclohexylureido)-thiazol-5-yl]-acrylic acid ethyl ester

→

3-[2-(3,3-dicyclohexylureido)-thiazol-5-yl]-propionic acid ethyl ester

Ausbeute 47.7%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe content was degassed
2. 2
   FiltrationThe mixture was filtered through celite
3. 3
   Einengenthe filtrate was concentrated
4. 4
   SonstigeThe residue was further purified by flash chromatography (silica, CH2Cl2-EtOAc 4:1

Vorschrift

To a solution of 3-[2-(3,3-dicyclohexylureido)-thiazol-5-yl]-acrylic acid ethyl ester (Example 257) (75 mg, 0.18 mmol) in methanol was added Pd/C (150 mg). The content was degassed and was placed under hydrogen atmosphere for 12 h. The mixture was filtered through celite, and the filtrate was concentrated. The residue was further purified by flash chromatography (silica, CH2Cl2-EtOAc 4:1 to give 3-[2-(3,3-dicyclohexylureido)-thiazol-5-yl]-propionic acid ethyl ester (35 mg) in 47% yield.

Quelle