Reaktion #619113

Reaktionsgleichung

2-Amino-5-formylthiazole

carbonyldiimidazole

dicyclohexylamine

→

1,1-dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe reaction mixture was concentrated
2. 2
   Sonstigethe crude product was purified by flash chromatography (silica, CH2Cl2-EtOAc, 4:1)

Vorschrift

2-Amino-5-formylthiazole (215 mg, 1.67 mmol), carbonyldiimidazole (275 mg, 1.70 mmol) and a catalytic amount of DMAP were heated together in 5 mL THF at 40° C. for 2 h. To this solution was added dicyclohexylamine (0.34 mL, 1.70 mmol) and the reaction mixture was stirred for an additional 6 h at room temperature. The reaction mixture was concentrated and the crude product was purified by flash chromatography (silica, CH2Cl2-EtOAc, 4:1) to obtain 1,1-dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea.

Quelle