Reaktion #61809

Reaktionsgleichung

water

3-Chloromethyl-5-(4-trifluoromethoxy-phenyl)-pyridine

4-(4-[1,2,3]triazol-1-yl-butyl)phenol

sodium hydride

→

title compound

Ausbeute 49.8%

3-[4-(4-[1,2,3]Triazol-1-yl-butyl)-phenoxymethyl]-5-(4-trifluoromethoxy-phenyl)-pyridine

Ausbeute 49.8%

Lösungsmittel

N,N-dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGstirred
2. 2
   workup.WAITcontinued at r.t. over night
3. 3
   Sonstigethe precipitate was isolated
4. 4
   Waschenwashed thoroughly with water, n-heptane and diisopropylether
5. 5
   SonstigeThe residue was dried at 40° C.

Vorschrift

A solution of 56 mg (0.24 mmol) 4-(4-[1,2,3]triazol-1-yl-butyl)phenol in 4.0 ml N,N-dimethylformamide was treated at 0° C. with 10 mg (0.24 mmol) of 60% sodium hydride and stirred at 0° C. for 30 min. Then 74 mg (0.24 mmol) 3-Chloromethyl-5-(4-trifluoromethoxy-phenyl)-pyridine were added and stirred continued at r.t. over night. After addition of 8 ml water, the precipitate was isolated, washed thoroughly with water, n-heptane and diisopropylether. The residue was dried at 40° C. to give 56 mg (49%) of the title compound as light brown powder.

Quelle