Reaktion #61791

Reaktionsgleichung

water

5-Chloromethyl-2-(3-trifluoromethyl-phenyl)-pyridine

4-(4-[1,2,3]triazol-1-yl-butyl)phenol

sodium hydride

→

title compound

Ausbeute 82.0%

5-[4-(4-[1,2,3]Triazol-1-yl-butyl)-phenoxymethyl]-2-(3-trifluoromethyl-phenyl)-pyridine

Ausbeute 82.0%

Lösungsmittel

N,N-dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGstirred
2. 2
   workup.WAITcontinued at r.t. over night
3. 3
   Sonstigethe precipitate was isolated
4. 4
   Waschenwashed thoroughly with water, methanol/water 1:1 and diisopropylether
5. 5
   SonstigeThe residue was dried at 40° C.

Vorschrift

A solution of 100 mg (0.46 mmol) 4-(4-[1,2,3]triazol-1-yl-butyl)phenol in 4.0 ml N,N-dimethylformamide was treated at 0° C. with 19 mg (0.48 mmol) of 60% sodium hydride and stirred at 0° C. for 30 min. Then 125 mg (0.46 mmol) 5-Chloromethyl-2-(3-trifluoromethyl-phenyl)-pyridine were added and stirred continued at r.t. over night. After addition of 8 ml water, the precipitate was isolated, washed thoroughly with water, methanol/water 1:1 and diisopropylether. The residue was dried at 40° C. to give 170 mg (82%) of the title compound as white powder.

Quelle