Reaktion #61776

Reaktionsgleichung

water

sodium hydride

4-(4-[1,2,3]triazol-1-yl-butyl)-phenol

3-chloromethyl-2-methyl-6-(3-trifluoromethyl-phenyl)-pyridine

→

title compound

Ausbeute 88.2%

2-Methyl-3-[4-(4-[1,2,3]triazol-1-yl-butyl)-phenoxymethyl]-6-(3-trifluoromethyl-phenyl)-pyridine

Ausbeute 88.2%

Lösungsmittel

N,N-dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGstirring
2. 2
   Sonstigecontinued at room temperature
3. 3
   Sonstige(r.t.) overnight
4. 4
   workup.STIRRINGwas stirred for 1 h
5. 5
   Sonstigethe formed precipitate isolated by filtration
6. 6
   Waschenwashed with water, water/methanol 1:1, n-heptane, and ether
7. 7
   SonstigeThe residue was dried at 40° C. in vacuum

Vorschrift

29 mg (0.73 mmol) of 60% sodium hydride were added to at 0° C. to a solution of 152 mg (0.70 mmol) 4-(4-[1,2,3]triazol-1-yl-butyl)-phenol in 8.0 ml N,N-dimethylformamide and stirred for 30 min. at 0° C. 200 mg (0.70 mmol) 3-chloromethyl-2-methyl-6-(3-trifluoromethyl-phenyl)-pyridine (WO 2005/049573) were given to the reaction mixture and stirring continued at room temperature (r.t.) overnight. After addition of 16 ml water the mixture was stirred for 1 h, the formed precipitate isolated by filtration, washed with water, water/methanol 1:1, n-heptane, and ether. The residue was dried at 40° C. in vacuum to give 288 mg (88%) of the title compound as beige powder.

Quelle