Reaktion #6177

Reaktionsgleichung

2-benzyl-3-tert.-butylthiopropionic acid ethyl ester

potassium hydroxide

→

title compound

Ausbeute 78.3%

2-benzyl-3-tert.-butylthio-propionic acid

Ausbeute 78.3%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenconcentrated by evaporation
2. 2
   workup.ADDITIONThe residue was diluted with water
3. 3
   Waschenwashed with ether
4. 4
   Sonstigeevaporated

Vorschrift

400 mg of 2-benzyl-3-tert.-butylthiopropionic acid ethyl ester was dissolved in 1.5 ml of methanol and then reacted with 5 ml of 2N potassium hydroxide solution. The mixture was stirred overnight at room temperature and concentrated by evaporation. The residue was diluted with water and washed with ether. The aqueous layer was acidified to pH 3 with 2N HCl, and then evaporated to give the title compound (280 mg, 78% yield). 1H NMR: 300 MHz spectrum consistent with proposed structure.

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