Reaktion #61761

Reaktionsgleichung

water

sodium hydride

3-methyl-4-(4-[1,2,3]triazol-1-yl-butyl)-phenol

5-chloromethyl-2-(4-trifluoromethoxy-phenyl)-pyridine

→

title compound

Ausbeute 56.4%

5-[3-Methyl-4-(4-[1,2,3]triazol-1-yl-butyl)-phenoxymethyl]-[2-(4-trifluoromethoxy-phenyl)]-pyridine

Ausbeute 56.4%

Lösungsmittel

N,N-dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGstirring
2. 2
   Sonstigecontinued at room temperature
3. 3
   Sonstige(r.t.) overnight
4. 4
   workup.STIRRINGwas stirred for 1 h
5. 5
   Sonstigethe formed precipitate isolated by filtration
6. 6
   Waschenwashed with water, methanol/water 1:1
7. 7
   SonstigeThe residue was purified by chromatography on silica (eluent: ethyl acetate/n-heptane 4:1)

Vorschrift

15 mg (0.60 mmol) of 95% sodium hydride were added at 0° C. to a solution of 116 mg (0.50 mmol) 3-methyl-4-(4-[1,2,3]triazol-1-yl-butyl)-phenol in 4.0 ml N,N-dimethylformamide and stirred for 30 min. at 0° C. 144 mg (0.50 mmol) 5-chloromethyl-2-(4-trifluoromethoxy-phenyl)-pyridine were given to the reaction mixture and stirring continued at room temperature (r.t.) overnight. After addition of 8 ml water the mixture was stirred for 1 h, the formed precipitate isolated by filtration, washed with water, methanol/water 1:1, and a small amount of ether. The residue was purified by chromatography on silica (eluent: ethyl acetate/n-heptane 4:1) to give 136 mg (56%) of the title compound as white powder.

Quelle