Reaktion #61759

Reaktionsgleichung

water

sodium hydride

3-methyl-4-(4-[1,2,3]triazol-1-yl-butyl)-phenol

2-chloromethyl-5-(4-trifluoromethyl-phenyl)-pyridine

→

title compound

Ausbeute 70.0%

2-[3-Methyl-4-(4-[1,2,3]triazol-1-yl-butyl)-phenoxymethyl]-5-(4-trifluoromethyl-phenyl)-pyridine

Ausbeute 70.0%

Lösungsmittel

N,N-dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGstirring
2. 2
   Sonstigecontinued at r.t overnight
3. 3
   workup.STIRRINGwas stirred for 1 h
4. 4
   Sonstigethe formed precipitate isolated by filtration
5. 5
   Waschenwashed with water, methanol/water 1:1
6. 6
   SonstigeThe residue was purified by chromatography on silica (eluent: ethyl acetate)

Vorschrift

8.0 mg (0.31 mmol) of 95% sodium hydride were added at 0° C. to a solution of 65 mg (0.28 mmol) 3-methyl-4-(4-[1,2,3]triazol-1-yl-butyl)-phenol in 3.0 ml N,N-dimethylformamide and stirred for 30 min. at 0° C. 76 mg (0.28 mmol) 2-chloromethyl-5-(4-trifluoromethyl-phenyl)-pyridine were given to the reaction mixture and stirring continued at r.t overnight. After addition of 6 ml water the mixture was stirred for 1 h, the formed precipitate isolated by filtration, washed with water, methanol/water 1:1. The residue was purified by chromatography on silica (eluent: ethyl acetate) to give 91 mg (70%) of the title compound as white powder.

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