Reaktion #61728

Reaktionsgleichung

1-(4-chlorophenyl)ethane-1-one

N,N Dimethylformamide diisopropylacetal

→

title compound

Ausbeute 99.0%

(2E)-3-Dimethylamino-1-(4-chlorophenyl)prop-2-en-1-one

Ausbeute 99.0%

Lösungsmittel

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturto reflux for 16 hours
2. 2
   FiltrationThe resulting solid was collected via filtration
3. 3
   Waschenwashed with hexanes

Vorschrift

A solution of 1-(4-chlorophenyl)ethane-1-one (35.0 g, 226 mmol) and N,N Dimethylformamide diisopropylacetal (35 mL) was heated to reflux for 16 hours. The reaction mixture was cooled to room temperature and treated with hexanes (50 mL). The resulting solid was collected via filtration and washed with hexanes to provide the title compound as a yellow solid (47.12 g, 99% yield): HPLC Retention Time; 6.45 min (Method B). M+1; 209.

Quelle