Reaktion #61719

Reaktionsgleichung

1-(4-chlorophenyl)ethan-1-one

dimethylformamide diisopropylacetal

→

title compound

(2E)-3-(Dimethylamino)-1-(4-chlorophenyl)prop-2-en-1-one

Lösungsmittel

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe resulting solid was collected via filtration
2. 2
   Waschenwashed with hexanes

Vorschrift

A solution of 1-(4-chlorophenyl)ethan-1-one (3.0 g, 19.3 mmol) and N,N, dimethylformamide diisopropylacetal (20 ml) was heated at 150° C. for 16 hours. The reaction mixture was cooled to 0° C. and treated with hexanes (20 ml). The resulting solid was collected via filtration and washed with hexanes to provide the title compound: EI-MS (m/z) 209 [M+1]+.

Quelle