Reaktion #61717

Reaktionsgleichung

Example 1

tert-Butyl(2R)-2-((3R)-3-{[(6-chloro-2-naphthyl)sulfonyl]amino}-2-oxopyrrolidin-1-yl)propanoate

chloroethylmorpholine hydrochloride

potassium carbonate

ethyl acetate

DMF

→

title compound

6-Chloro-N-{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl}-N-(2-morpholin-4-ylethyl)naphthalene-2-sulfonamide formate

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture was then heated at 80° C. for 8 h
2. 2
   Temperaturcooled
3. 3
   ExtraktionThe organic extract
4. 4
   Trocknenwas dried (over magnesium sulphate)
5. 5
   Einengenconcentrated under reduced pressure
6. 6
   SonstigeThe residue was purified

Vorschrift

Example 1 (0.05 g) was dissolved in DMF (1 ml) and treated with chloroethylmorpholine hydrochloride (0.062 g) and potassium carbonate (0.093 g), and stirred at 40° C. for 2 h. The mixture was then heated at 80° C. for 8 h, cooled and treated with ethyl acetate and water. The organic extract was dried (over magnesium sulphate) and concentrated under reduced pressure. The residue was purified using mass directed preparative h.p.l.c. to give the title compound (0.018 g) as a white solid.

Quelle