Reaktion #617165

Reaktionsgleichung

thiourea

dimethoxymethyl-dimethyl-amine

triethylamine

2-bromo-1-(chloro-phenyl)-ethanone

→

N′-[5-(2-Chloro-benzoyl)-thiazol-2-yl]-N,N-dimethyl-formamidine

Lösungsmittel

methanol

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated
2. 2
   Temperaturto reflux for 30 minutes
3. 3
   Temperaturto cool
4. 4
   TemperaturThe mixture was heated
5. 5
   Temperaturto reflux for 4 hours
6. 6
   SonstigeThe solvent was removed

Vorschrift

A mixture of thiourea (4.95 g, 65.0 mmol) and dimethoxymethyl-dimethyl-amine (23.2 g, 195 mmol) in methanol (80 mL) was heated to reflux for 30 minutes. After allowing the mixture to cool, triethylamine (19.8 g, 195 mmol) and a solution of 2-bromo-1-(chloro-phenyl)-ethanone (crude from last step) in methanol (50 mL) were added. The mixture was heated to reflux for 4 hours. The solvent was removed and the residue was used directly in the next procedure.

Quelle