Reaktion #61699

Reaktionsgleichung

tert-butyl(2S)-2-((3S)-3-{[(benzyloxy)carbonyl]amino}-2-oxopyrrolidin-1-yl)propanoate

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title compound

Ausbeute 101.3%

tert-Butyl(2S)-2-[(3S)-3-amino-2-oxopyrrolidin-1-yl]propanoate

Ausbeute 101.3%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe reaction mixture was filtered through Harbolite™
2. 2
   Einengenthe filtrate was concentrated under reduced pressure

Vorschrift

A mixture of tert-butyl(2S)-2-((3S)-3-{[(benzyloxy)carbonyl]amino}-2-oxopyrrolidin-1-yl)propanoate (2.82 g), 10% palladium on carbon (0.3 g) and ethanol (150 ml) was stirred under an atmosphere of hydrogen for 18 h. The reaction mixture was filtered through Harbolite™ and the filtrate was concentrated under reduced pressure to give the title compound (1.8 g) as a pale yellow oil.

Quelle